1: With potassium hydroxide; methyltriethyl ammonium chloride in water; toluene T=100°C; 15.25 h; 2: With hydrogen bromide in water; toluene Product distribution / selectivity;
1: UK-88862 With sodium hydroxide; water in ethyl acetate T=25 - 35°C; 0.25 h; 2: 2-(2,3-dihydrobenzofuran-5-yl)ethylchloride With triethylamine T=95°C; 15 h; 3: With hydrogen bromide in water; acetone 1 h; Product distribution / selectivity;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2008/100651 A2, 2008 ;
Location in patent: Page/Page column 39-40 ;