(S)-1-对甲苯磺酰基-3-(1-氰基-1,1-二苯甲基)吡咯烷合成路线 (共 3 条)
反应条件
sodium hydroxide; tetrabutylammomium bromide in toluene T=25 - 60°C; 4.16667 - 6.16667 h;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2008/100651 A2, 2008 ;
Location in patent: Page/Page column 15; 34-35 ;
反应条件
1: α,α-diphenylacetonitrile With potassium hydroxide in N,N-dimethyl-formamide 2 h; 2: (+)-3-chloro-1-(toluene-4-sulfonyl)-pyrrolidine in N,N-dimethyl-formamide T=95 - 100°C; 5 h;
参考文献
WO2008/126106 A2, ;
Page/Page column 13; 24-25 ;
反应条件
1: With hydrogen bromide; phenol in water 3 h; Heating / reflux; 2: With sodium hydroxide in water pH=9;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2009/5431 A1, 2009 ;
Location in patent: Page/Page column 32 ;
US 20090005431 A1