(S)-alpha,alpha-二苯-3-吡咯烷乙酰胺合成路线 （共 7 条）
反应条件
ammonium formate; palladium on activated charcoal in methanol T=50°C; 3 h;
参考文献
Theravance, Inc.
Patent: US2005/277688 A1, 2005 ;
Location in patent: Page/Page column 11 ;
US 20050277688 A1
反应条件
ammonium formate; palladium 10 on activated carbon in methanol; water 5 h; HeatingReflux;
参考文献
MEDICHEM, S.A.
Patent: WO2009/153649 A1, 2009 ;
Location in patent: Page/Page column 11; 12 ;
反应条件
hydrogenchloride in methanol T=20 - 30°C; 7 h;
参考文献
Pramanik, Chinmoy; Bapat, Kiran; Chaudhari, Ashok; Tripathy, Narendra K.; Gurjar, Mukund K.
Organic Process Research and Development, 2012 , vol. 16, # 10 p. 1591 - 1597
反应条件
1: With hydrogen bromide; phenol in water 3 h; Heating / reflux; 2: With sodium hydroxide in water pH=9;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2009/5431 A1, 2009 ;
Location in patent: Page/Page column 32 ;
US 20090005431 A1
反应条件
1.1: sulfuric acid / 12 h / 85 - 90 °C 2.1: ethanol / 1 h 3.1: potassium carbonate / water / 0.5 h / 25 - 30 °C 3.2: 12 h / 25 - 75 °C 4.1: hydrogen bromide / water; acetone / 7 h / 0 - 20 °C View Scheme
参考文献
Pramanik, Chinmoy; Bapat, Kiran; Chaudhari, Ashok; Tripathy, Narendra K.; Gurjar, Mukund K.
Organic Process Research and Development, 2012 , vol. 16, # 10 p. 1591 - 1597
反应条件
1.1: sulfuric acid / 12 h / 85 - 90 °C 2.1: ethanol / 1 h 3.1: potassium carbonate / water / 0.5 h / 25 - 30 °C 3.2: 12 h / 25 - 75 °C View Scheme
参考文献
Pramanik, Chinmoy; Bapat, Kiran; Chaudhari, Ashok; Tripathy, Narendra K.; Gurjar, Mukund K.
Organic Process Research and Development, 2012 , vol. 16, # 10 p. 1591 - 1597
反应条件
sulfuric acid in water T=85 - 90°C; 14 h;
参考文献
MEDICHEM, S.A.
Patent: WO2009/153649 A1, 2009 ;
Location in patent: Page/Page column 12 ;
