1-苄基-4-(4-甲氧基苯基)四氢吡啶合成路线 （共 12 条）
反应条件
1: 1-Phenylmethyl-piperidin-4-one With tris-(dibenzylideneacetone)dipalladium(0); toluene-4-sulfonic acid hydrazide; lithium tert-butylate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in 1,4-dioxane 0.0166667 h; Inert atmosphere; 2: 1-bromo-4-methoxy-benzene in 1,4-dioxane T=110°C; Inert atmosphere;
参考文献
Barluenga, Jose; Tomas-Gamasa, Maria; Moriel, Patricia; Aznar, Fernando; Valdes, Carlos
Chemistry - A European Journal, 2008 , vol. 14, # 16 p. 4792 - 4795
反应条件
tetrabutyl ammonium fluoride; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in tetrahydrofuran T=20°C;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2008/79255 A1, 2008 ;
Location in patent: Page/Page column 19-22 ;
反应条件
tetrabutyl ammonium fluoride; biphenyl-2-yl-di-tert-butyl-phosphane; palladium(II) bromide in tetrahydrofuran T=50°C;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2008/79255 A1, 2008 ;
Location in patent: Page/Page column 28-29 ;
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; water T=50°C; 1 h;
参考文献
Tsukamoto, Hirokazu; Kondo, Yoshinori
Angewandte Chemie - International Edition, 2008 , vol. 47, # 26 p. 4851 - 4854
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; water T=50°C; 1 h;
参考文献
Tsukamoto, Hirokazu; Kondo, Yoshinori
Angewandte Chemie - International Edition, 2008 , vol. 47, # 26 p. 4851 - 4854
反应条件
toluene-4-sulfonic acid in toluene Heating; Yield given;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 10 p. 1397 - 1402
反应条件
1: 1-Phenylmethyl-piperidin-4-one With tris-(dibenzylideneacetone)dipalladium(0); toluene-4-sulfonic acid hydrazide; lithium tert-butylate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in 1,4-dioxane 0.0166667 h; Inert atmosphere; 2: 1-methoxy-4-chlorobenzene in 1,4-dioxane T=110°C; 6 h; Inert atmosphere;
参考文献
Barluenga, Jose; Tomas-Gamasa, Maria; Moriel, Patricia; Aznar, Fernando; Valdes, Carlos
Chemistry - A European Journal, 2008 , vol. 14, # 16 p. 4792 - 4795
反应条件
1.1: n-BuLi / hexane; tetrahydrofuran / -70 - 1 °C 1.2: tetrahydrofuran / 20 °C 2.1: p-toluenesulfonic acid monohydrate / toluene / Heating View Scheme
参考文献
Bioorganic and medicinal chemistry, , vol. 12, # 16 p. 4543 - 4550
反应条件
1.1: n-BuLi / hexane; tetrahydrofuran / -70 - 1 °C 1.2: tetrahydrofuran / 20 °C 2.1: p-toluenesulfonic acid monohydrate / toluene / Heating View Scheme
参考文献
Bioorganic and medicinal chemistry, , vol. 12, # 16 p. 4543 - 4550
