1: 84 percent / perchloric acid, acetic acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min, 3.) reflux, 60 h 2: 96 percent / thionyl chloride / heptane / 1.) RT, 10 min, 2.) reflux, 1 d View Scheme

methanol; perchloric acid; acetic acid 1.) 0 deg C, 10 min, 2.) RT, 30 min, 3.) reflux, 60 h;

perchloric acid; acetic acid 1.) 0 deg C, 10 min, 2.) RT, 30 min, 3.) reflux, 60 h;

1: 84 percent / perchloric acid, acetic acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min, 3.) reflux, 60 h 2: 96 percent / thionyl chloride / heptane / 1.) RT, 10 min, 2.) reflux, 1 d 3: 76 percent / triethylamine / CH2Cl2 / 1.) 0 deg C, 3 h, 2.) RT, 2 d View Scheme

1: 84 percent / perchloric acid, acetic acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min, 3.) reflux, 60 h 2: 96 percent / thionyl chloride / heptane / 1.) RT, 10 min, 2.) reflux, 1 d 3: 83 percent / tetrahydrofuran / 1.) 0 deg C, 4 h, 2.) RT, 2 d View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '4122952', constants.ctx, '0')">sodium hydride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102551', constants.ctx, '0')">1,4-dioxane</a> <br />&nbsp;1.) RT, 10 min, 2.) reflux, 32 h;&nbsp;<br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />&nbsp;1.) 0 deg C, 20 min, 2.) RT, 1 h;&nbsp;<br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '4122952', constants.ctx, '0')">sodium hydride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102551', constants.ctx, '0')">1,4-dioxane</a> <br />&nbsp;1.) 4 h, 2.) RT, 2 d, 3.) reflux, 2 d;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 90 percent / triethylamine / CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) RT, 2 d<br />2: 93 percent / anhyd. potassium carbonate / dimethylformamide / 90 h / 130 &deg;C<br /> <br /> &nbsp;