hydrogenchloride in tetrahydrofuran T=22°C; 16 h;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '8127930', constants.ctx, '0')">sodium iodide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '8973685', constants.ctx, '0')">zinc</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1209237', constants.ctx, '0')">ethylene glycol dimethyl ether</a> <br />T=90&deg;C;&nbsp;24&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 55 percent / NH₃, Li / tetrahydrofuran / 3 h / -50 &deg;C<br />2: 92 percent / pyridine / CHCl₃ / 48 h / 22 &deg;C<br />3: 71 percent / NaI, Zn, H₂O / 1,2-dimethoxy-ethane / 24 h / 90 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 92 percent / pyridine / CHCl₃ / 48 h / 22 &deg;C<br />2: 71 percent / NaI, Zn, H₂O / 1,2-dimethoxy-ethane / 24 h / 90 &deg;C<br /> <br /> &nbsp;