3’,5’-二氟-4’-羟基苯乙酮合成路线 （共 4 条）
反应条件
hydrogen bromide in water 30 h; Heating / reflux;
参考文献
Cephalon, Inc.
Patent: US2008/27041 A1, 2008 ;
Location in patent: Page/Page column 101 ;
US 20080027041 A1
反应条件
aluminium trichloride in nitrobenzene T=140 - 150°C; 5 h;
参考文献
Xu, Linxiao; Giese, Roger W.
Journal of Fluorine Chemistry, 1994 , vol. 67, # 1 p. 47 - 52
反应条件
1: 90 percent / pyridine / toluene / 5 h 2: 52 percent / AlCl3 / nitrobenzene / 5 h / 140 - 150 °C View Scheme
参考文献
Xu, Linxiao; Giese, Roger W.
Journal of Fluorine Chemistry, 1994 , vol. 67, # 1 p. 47 - 52
反应条件
formic acid; fluorine T=10°C; Fluorination; 1.75 h; Title compound not separated from byproducts;
参考文献
Chambers, Richard D.; Hutchinson, John; Sparrowhawk, Matthew E.; Sandford, Graham; Moilliet, John S.; Thomson, Julie
Journal of Fluorine Chemistry, 2000 , vol. 102, # 1-2 p. 169 - 173
