1: 100 percent / anhyd. MgSO4 / toluene / 0.83 h / 0 °C 2: NEt3 / CH2Cl2 / Ambient temperature 3: 70 percent / HCl 4: 93 percent / pyridine / CH2Cl2 / 0.17 h / 0 °C 5: 92 percent / H2 / 10percent Pd/C / ethyl acetate / Ambient temperature 6: 85 percent / 1.) 6 M HCl, 2.) ion exchange resin (H+) / 1.) 4 h, 100 deg C View Scheme

1: MgSO4 / toluene / 0 °C 2: Et3N / CH2Cl2 / Ambient temperature 3: 70 percent / HCl gas / 1) rt, overnight, 2) 60 deg C, 3 h 4: 93 percent / pyridine / CH2Cl2 / 0.17 h / 0 °C 5: 92 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr / Ambient temperature 6: 6 M HCl / 4.5 h / 100 °C View Scheme

1.1: 61 percent / tetrahydrofuran / 3 h / 0 °C 2.1: 88 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C 3.1: 99 percent / Amberlyst(R)-15H / CH2Cl2 / 20 °C 4.1: ozone / CH2Cl2 / -78 - 20 °C 4.2: 68 percent / LiAlH4 / tetrahydrofuran / 2 h / 20 °C View Scheme