1.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 16 h / 21 °C 2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere 3.1: sodium hydroxide; methanol / tetrahydrofuran / 16 h / 80 °C 4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 21 °C 4.2: 18 h / 21 °C View Scheme

1.1: boron trichloride / dichloromethane / 0.5 h / -15 °C / Inert atmosphere 1.2: Cooling with ice 2.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 0.83 h / 0 °C / Inert atmosphere 3.1: potassium fluoride; sodium bromide / tetrakis(triphenylphosphine) palladium(0) / toluene; water / 18 h / 100 °C / Inert atmosphere 4.1: hydrogenchloride; hydrogen / palladium 10 on activated carbon / ethyl acetate; water / 16 h / 21 °C 5.1: triethylamine / dichloromethane / 2 h / 0 °C / Cooling with ice 6.1: potassium hydroxide; water / ethanol / 1 h / Reflux View Scheme