反应条件
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere
2.1: sodium hydroxide; methanol / tetrahydrofuran / 16 h / 80 °C
3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.17 h / 21 °C
3.2: 18 h / 21 °C
View Scheme
参考文献
GLAXO GROUP LIMITED; JOHNS, Brian Alvin; SHOTWELL, John Brad; HAIGH, David
Patent: WO2012/67663 A1, 2012 ;
