1.1: 1,3-diamino-propane / 1 h / Reflux; Inert atmosphere 2.1: potassium hydroxide / N,N-dimethyl-formamide / 0.25 h / Inert atmosphere 2.2: 0.25 h / 20 °C / Inert atmosphere 3.1: Grubb's 2nd generation catalyst; toluene-4-sulfonic acid / dichloromethane / 18 h / 20 °C / Inert atmosphere View Scheme

1.1: 1,3-diamino-propane / 1 h / Reflux; Inert atmosphere 2.1: potassium hydroxide / N,N-dimethyl-formamide / 0.25 h / Inert atmosphere 2.2: 0.25 h / 20 °C / Inert atmosphere 3.1: Grubb's 2nd generation catalyst; toluene-4-sulfonic acid / dichloromethane / 18 h / 20 °C / Inert atmosphere 4.1: palladium 10 on activated carbon; hydrogen / methanol / 3 h / 20 °C / 760.05 Torr View Scheme