2-丁基-5-硝基苯并呋喃合成路线 (共 23 条)
反应条件
1: NaOH / 0.5 h / 90 °C 2: 87 percent / K2CO3 / dimethylformamide / 3.5 h / 92 - 94 °C 3: 80 percent / NaOH / Heating 4: acetic anhydride; sodium acetate; acetic acid / 3 h / Heating View Scheme
参考文献
Polish Journal of Chemistry, , vol. 78, # 10 p. 1865 - 1869
反应条件
1: NaOH / 2 h / 50 °C 2: 87 percent / K2CO3 / dimethylformamide / 3.5 h / 92 - 94 °C 3: 80 percent / NaOH / Heating 4: acetic anhydride; sodium acetate; acetic acid / 3 h / Heating View Scheme
参考文献
Polish Journal of Chemistry, , vol. 78, # 10 p. 1865 - 1869
反应条件
sodium acetate; acetic anhydride; acetic acid 3 h; Heating;
参考文献
Polish Journal of Chemistry, , vol. 78, # 10 p. 1865 - 1869
反应条件
1: 80 percent / NaOH / Heating 2: acetic anhydride; sodium acetate; acetic acid / 3 h / Heating View Scheme
参考文献
Polish Journal of Chemistry, , vol. 78, # 10 p. 1865 - 1869
反应条件
1: in water T=0 - 22°C; 1.5 h; 2: With anhydrous iron chloride T=20 - 22°C; 1.5 h;
参考文献
US2004/10032 A1, ;
Page/Page column 5 ;
反应条件
ammonium formate; platinum(IV) oxide in ethanol T=20°C; P=18751.9 Torr;
参考文献
Fino, Noel; Leroy, Corinne
Patent: US2004/48921 A1, 2004 ;
Location in patent: Page/Page column 4 ;
反应条件
1.1: AlCl3, aluminium chloride / chlorobenzene / 2 h / 25 °C / Reflux 2.1: AlCl3, aluminium chloride / chlorobenzene / 2 h / 75 °C 2.2: 0.5 h / 5 - 65 °C 3.1: potassium carbonate / butanone / 20 h / 85 °C 3.3: 0.5 h / 25 - 65 °C 4.1: potassium carbonate / toluene; water 5.1: hydrogen / Raney Nickel / methanol / 8 h / 55 °C / 3677.86 Torr 5.2: 0.5 h / 25 - 65 °C 6.1: potassium carbonate / toluene; water / 1 h / 35 °C 7.1: toluene / 3.5 h / 108 °C 7.2: 0.5 h / 60 °C View Scheme
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash, Dhar; PATEL, Vipul, Kantibhai; PANDYA, Jayesh, Mohanlal
Patent: WO2012/32545 A1, 2012 ;
反应条件
1: With methyltrichloromonosilane; anhydrous iron chloride in chlorobenzene T=20 - 40°C; 3.45 - 5 h; 2: With ethanol in chlorobenzene T=0 - 30°C; 0.45 - 0.5 h; Product distribution / selectivity;
参考文献
Shasun Pharma Solutions Limited
Patent: US2008/154049 A1, 2008 ;
Location in patent: Page/Page column 7-9 ;
反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 4 h / 25 °C 2.1: AlCl3, aluminium chloride / chlorobenzene / 4 h / 85 °C 2.2: 35 - 60 °C View Scheme
参考文献
Mahender; Saravanan; Sridhar; Chandrashekar; Kumar, L. Jaydeep; Jayashree; Bandichhor, Rakeshwar
Organic Process Research and Development, 2014 , vol. 18, # 1 p. 157 - 162
反应条件
1.1: AlCl3, aluminium chloride / chlorobenzene / 2 h / 25 °C / Reflux 2.1: AlCl3, aluminium chloride / chlorobenzene / 2 h / 75 °C 2.2: 0.5 h / 5 - 65 °C 3.1: potassium carbonate / butanone / 20 h / 85 °C 3.3: 0.5 h / 25 - 65 °C 4.1: potassium carbonate / toluene; water 5.1: hydrogen / Raney Nickel / methanol / 8 h / 55 °C / 3677.86 Torr 5.2: 0.5 h / 25 - 65 °C 6.1: potassium carbonate / toluene; water / 1 h / 35 °C View Scheme