3-(叔丁基)-1-甲基-1H-吡唑-5-羧酸乙酯合成路线 （共 6 条）
反应条件
in toluene T=90°C; 2.5 h;
参考文献
Galapagos NV
Patent: WO2009/71706 A1, 2009 ;
Location in patent: Page/Page column 43-44 ;
WO 2009/071706 A1
反应条件
in ethanol T=20 - 80°C;
参考文献
US2011/218197 A1, ;
Page/Page column 44 ;
US 20110218197 A1
反应条件
in acetic acid 18 h; Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 62, # 17 p. 5908 - 5919
反应条件
1: 93 percent / NaOEt / ethanol / 5 h / Ambient temperature 2: 69 percent / acetic acid / 18 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 62, # 17 p. 5908 - 5919
反应条件
1: 93 percent / aq. NaOH / ethanol / 18 h / Ambient temperature 2: 97 percent / (COCl)2, DMF / CH2Cl2 / 16 h / Ambient temperature View Scheme
参考文献
Parlow, John J.; Mischke, Deborah A.; Woodard, Scott S.
Journal of Organic Chemistry, 1997 , vol. 62, # 17 p. 5908 - 5919
反应条件
sodium hydroxide in ethanol 18 h; Ambient temperature;
参考文献
Parlow, John J.; Mischke, Deborah A.; Woodard, Scott S.
Journal of Organic Chemistry, 1997 , vol. 62, # 17 p. 5908 - 5919
