1: sodium methylate / methanol; tetrahydrofuran / 6 h / 20 °C 2: palladium 10 on activated carbon; hydrogen / tetrahydrofuran; ethanol / 2 h / 20 °C / 750.08 Torr View Scheme

1: sodium methylate / methanol; tetrahydrofuran / 6 h / 20 °C 2: palladium 10 on activated carbon; hydrogen / tetrahydrofuran; ethanol / 2 h / 20 °C / 750.08 Torr 3: potassium carbonate / N,N-dimethyl-formamide / 6 h / 20 °C 4: potassium carbonate / N,N-dimethyl-formamide / 10 h / 20 °C / |Inert atmosphere 5: sodium methylate / methanol; tetrahydrofuran / 6 h / 20 °C 6: palladium 10 on activated carbon; hydrogen / tetrahydrofuran; ethanol / 2 h / 20 °C / 750.08 Torr View Scheme

1.1: methanol; sodium methylate / tetrahydrofuran / 20 °C 2.1: sodium hypochlorite; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; tetrabutylammomium bromide; potassium carbonate; potassium bromide / dichloromethane / 1 h 2.2: 12 h View Scheme