反应条件
1.1: 1,4-diaza-bicyclo[2.2.2]octane / N,N-dimethyl-formamide / 0.5 h 1.2: 1 h 2.1: lithium hydroxide hydrate; water / tetrahydrofuran / 4 h / 20 °C 3.1: 1-propanephosphonic acid cyclic anhydride; N-ethyl-N,N-diisopropylamine / dichloromethane; ethyl acetate / 0.5 h / -40 °C View Scheme
参考文献
KARYOPHARM THERAPEUTICS, INC.; SANDANAYAKA, Vincent, P.; SHACHAM, Sharon; MCCAULEY, Dilara; SHECHTER, Sharon
Patent: WO2013/19548 A1, 2013 ;
WO 2013/019548 A1
