4,5,5-三甲基-2-氧代-2,5-二氢-3-呋喃甲腈合成路线 （共 3 条）
反应条件
1: anhydrous xylene / 5 h / |Reflux 2: hydrogenchloride; acetic acid / 4 h / |Reflux 3: phosphorus pentachloride / 130 - 150 °C View Scheme
参考文献
Hovhannisyan, Anna; Pham, The Hien; Bouvier, Dominique; Piroyan, Alexander; Dufau, Laure; Qin, Lixian; Cheng, Yan; Melikyan, Gagik; Reboud-Ravaux, Michele; Bouvier-Durand, Michelle
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 6 p. 1571 - 1580
反应条件
1: anhydrous xylene / 3 h / Reflux 2: hydrogenchloride; acetic acid / 4 h / Reflux View Scheme
参考文献
Pham, The Hien; Hovhannisyan, Anna; Bouvier, Dominique; Tian, Lei; Reboud-Ravaux, Michele; Melikyan, Gagik; Bouvier-Durand, Michelle
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3822 - 3827
反应条件
hydroxylamine hydrochloride; potassium carbonate in ethanol
T=80 - 82°C; 10 h;
参考文献
Avetisyan, A. A.; Dzhandzhapanyan, A. N.; Galstyan, A. V.; Karagez, S. Kh.; Votyakov, V. I.; et al.
Pharmaceutical Chemistry Journal, 1982 , vol. 16, # 8 p. 580 - 582
Khimiko-Farmatsevticheskii Zhurnal, 1982 , vol. 16, # 8 p. 917 - 920
