1.1: hydrogenchloride; water / 5 h / 70 °C 1.2: pH 10 / Alkaline conditions 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 5 °C View Scheme

1: With hydrogenchloride; water T=70°C; 5 h; 2: pH=10; Alkaline conditions;

<b>Multi-step reaction with 5 steps<br /> </b>1.1: bromine / dichloromethane; water / 20 &deg;C / pH 8.5<br />1.2: pH 8.5 / Alkaline conditions<br />2.1: triethylamine / dichloromethane / 0.75 h / Cooling with ice<br />3.1: potassium phosphate; copper; copper(l) iodide / 2-(dimethylamino)-ethanol / 24 h / 80 &deg;C<br />4.1: hydrogenchloride / diethyl ether / Cooling with ice<br />5.1: triethylamine / acetonitrile / Cooling with ice<br /> <br /> &nbsp;