hydrogen; boric acid; nickel in methanol; water 1 h; Heating;

1: 1.) N-chlorosuccinimide, 2.) KHCO3, water / 1.) AcOEt, 65 deg C, 0.5 h, 2.) 25 deg C, 24 h 2: 64 percent / sodium acetate, KF / acetic acid / 2 h / Heating 3: 75 percent / NaOH / methanol / 24 h 4: H2, boric acid / Raney-Ni / methanol; H2O / 1 h / Heating View Scheme

1: 1.) N-chlorosuccinimide, 2.) KHCO3, water / 1.) AcOEt, 65 deg C, 0.5 h, 2.) 25 deg C, 24 h 2: 64 percent / sodium acetate, KF / acetic acid / 2 h / Heating 3: 75 percent / NaOH / methanol / 24 h 4: H2, boric acid / Raney-Ni / methanol; H2O / 1 h / Heating View Scheme

1: 75 percent / NaOH / methanol / 24 h 2: H2, boric acid / Raney-Ni / methanol; H2O / 1 h / Heating View Scheme

1: 64 percent / sodium acetate, KF / acetic acid / 2 h / Heating 2: 75 percent / NaOH / methanol / 24 h 3: H2, boric acid / Raney-Ni / methanol; H2O / 1 h / Heating View Scheme

sodium hydroxide 1 h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

sodium hydroxide 1 h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;