3-氟丙基8-氟-5-甲基-6-氧代-4H-咪唑并[1,5-a][1,4]苯并二氮杂卓-3-羧酸酯合成路线 （共 3 条）
反应条件
in dichloromethane T=20°C; 16 h;
参考文献
Jackson, Alexander; Guilbert, Benedicte B.; Plant, Stuart D.; Goggi, Julian; Battle, Mark R.; Woodcraft, John L.; Gaeta, Alessandra; Jones, Clare L.; Bouvet, Denis R.; Jones, Paul A.; O'Shea, Dennis M.; Zheng, Penny Hao; Brown, Samantha L.; Ewan, Amanda L.; Trigg, William
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 821 - 826
反应条件
1: sodium hydroxide / tetrahydrofuran; water / 20 °C 2: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 2 h / |Reflux 3: dichloromethane / 16 h / 20 °C View Scheme
参考文献
Jackson, Alexander; Guilbert, Benedicte B.; Plant, Stuart D.; Goggi, Julian; Battle, Mark R.; Woodcraft, John L.; Gaeta, Alessandra; Jones, Clare L.; Bouvet, Denis R.; Jones, Paul A.; O'Shea, Dennis M.; Zheng, Penny Hao; Brown, Samantha L.; Ewan, Amanda L.; Trigg, William
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 821 - 826
反应条件
1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 2 h / |Reflux 2: dichloromethane / 16 h / 20 °C View Scheme
参考文献
Jackson, Alexander; Guilbert, Benedicte B.; Plant, Stuart D.; Goggi, Julian; Battle, Mark R.; Woodcraft, John L.; Gaeta, Alessandra; Jones, Clare L.; Bouvet, Denis R.; Jones, Paul A.; O'Shea, Dennis M.; Zheng, Penny Hao; Brown, Samantha L.; Ewan, Amanda L.; Trigg, William
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 821 - 826
