(R)-(+)-N-甲氧基甲基-N-(三甲基甲硅基)甲基-1-苯乙胺合成路线 (共 3 条)
反应条件
potassium carbonate in water T=0°C; 2.5 h;
参考文献
Gerlach, Kai; Hoffmann; Wartchow
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 22 p. 3867 - 3872
反应条件
1: (R)-1-phenyl-ethyl-amine; chloromethyl-trimethyl-silane in dimethyl sulfoxide T=100°C; 12 h; Inert atmosphereLarge scale; 2: methanol; formaldehyd With potassium carbonate T=10°C; 2 h; Large scale;
参考文献
Organic Process Research and Development, , vol. 8, # 6 p. 897 - 902
反应条件
1: 81 percent / K2CO3 / acetonitrile / 4 h / Heating 2: 64 percent / K2CO3 / H2O / 2.5 h / 0 °C View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 22 p. 3867 - 3872