咪唑并[1,2-A]吡啶-8-甲酸甲酯合成路线 （共 12 条）
反应条件
hydrogen bromide; sodium hydrogencarbonate in ethanol
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5498774 A1, 1996 ;
反应条件
in ethanol 18 h; Heating / reflux;
参考文献
GLOBAL BLOOD THERAPEUTICS, INC.; CYTOKINETICS, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; METCALF, Brian; CHUANG, Chihyuan; WARRINGTON, Jeffrey; PAULVANNAN, Kumar; JACOBSON, Matthew P.; HUA, Lan; MORGAN, Bradley
Patent: WO2013/102142 A1, 2013 ;
Location in patent: Paragraph 0154 ;
反应条件
thionyl chloride 8 h; Reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; COOK, Brian Nicholas; KUZMICH, Daniel
Patent: WO2011/56440 A1, 2011 ;
Location in patent: Page/Page column 46-47 ;
WO 2011/056440 A1
反应条件
in ethanol 18 h; Heating / reflux;
参考文献
Barber, Christopher Gordon; Bunnage, Mark Edward; Harvey, John Wilson; Mathias, John Paul
Patent: US2005/20611 A1, 2005 ;
Location in patent: Page/Page column 28 ;
反应条件
1: 72 percent / butan-1-ol / Heating 2: 38 percent / conc. H2SO4 / 48 h / Heating View Scheme
参考文献
Yamanaka; Miyake; Suda; Ohhara; Ogawa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1556 - 1567
反应条件
sulfuric acid 48 h; Heating;
参考文献
Yamanaka; Miyake; Suda; Ohhara; Ogawa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1556 - 1567
反应条件
1: ethanol; water / 14 h / Reflux 2: thionyl chloride / 8 h / Reflux View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; COOK, Brian Nicholas; KUZMICH, Daniel
Patent: WO2011/56440 A1, 2011 ;
WO 2011/056440 A1
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran; diethyl ether T=20°C; 6 h; Inert atmosphere; 2: With sodium hydroxide in tetrahydrofuran; diethyl ether; water T=0 - 20°C; 0.25 h;
参考文献
GLOBAL BLOOD THERAPEUTICS, INC.; CYTOKINETICS, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; METCALF, Brian; CHUANG, Chihyuan; WARRINGTON, Jeffrey; PAULVANNAN, Kumar; JACOBSON, Matthew P.; HUA, Lan; MORGAN, Bradley
Patent: WO2013/102142 A1, 2013 ;
Location in patent: Paragraph 0155 ;
反应条件
diisobutylaluminium hydride in dichloromethane T=-60°C;
参考文献
Yamanaka; Miyake; Suda; Ohhara; Ogawa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1556 - 1567
反应条件
1: With lithium hydroxide; water in methanol T=20°C; 1.5 h; 2: With hydrogenchloride in water
参考文献
Pfizer Inc
Patent: US2005/20639 A1, 2005 ;
Location in patent: Page 15 ;
