咪唑并[1,2-A]吡啶-8-甲酸甲酯合成路线 （共 12 条）
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 6 h / 20 °C / |Inert atmosphere 1.2: 0.25 h / 0 - 20 °C 2.1: thionyl chloride / 8 h / 70 - 80 °C / |Inert atmosphere View Scheme
参考文献
GLOBAL BLOOD THERAPEUTICS, INC.; CYTOKINETICS, INC.; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; METCALF, Brian; CHUANG, Chihyuan; WARRINGTON, Jeffrey; PAULVANNAN, Kumar; JACOBSON, Matthew P.; HUA, Lan; MORGAN, Bradley
Patent: WO2013/102142 A1, 2013 ;
反应条件
N-iodo-succinimide in acetonitrile
T=20°C; 2 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; COOK, Brian Nicholas; KUZMICH, Daniel
Patent: WO2011/56440 A1, 2011 ;
Location in patent: Page/Page column 46-47 ;
WO 2011/056440 A1
