N-[(4aR,6R,7R,8R,8aS)-6-苄氧基-8-羟基-2-苯基-4,4A,6,7,8,8A-六氢吡喃并[5,6-d][1,3]二恶英-7-基]乙酰胺 合成路线 (共 9 条)
→
反应条件
13343-61-8 N-[(4aR,6R,7R,8R,8aS)-6-苄氧基-8-羟基-2-苯基-4,4A,6,7,8,8A-六氢吡喃并[5,6-d][1,3]二恶英-7-基]乙酰胺
反应条件
toluene-4-sulfonic acid; sodium methylate in methanol; acetonitrile
→
反应条件
13343-61-8 N-[(4aR,6R,7R,8R,8aS)-6-苄氧基-8-羟基-2-苯基-4,4A,6,7,8,8A-六氢吡喃并[5,6-d][1,3]二恶英-7-基]乙酰胺 +
反应条件
toluene-4-sulfonic acid in N,N-dimethyl-formamide T=55°C;
参考文献
WO2012/103990 A1, ;
Page/Page column 45 ;
→
反应条件
13343-61-8 N-[(4aR,6R,7R,8R,8aS)-6-苄氧基-8-羟基-2-苯基-4,4A,6,7,8,8A-六氢吡喃并[5,6-d][1,3]二恶英-7-基]乙酰胺
反应条件
toluene-4-sulfonic acid in acetonitrile T=60°C; 60 h;
参考文献
Canadian Journal of Chemistry, , vol. 70, # 10 p. 2607 - 2617
→
反应条件
13343-61-8 N-[(4aR,6R,7R,8R,8aS)-6-苄氧基-8-羟基-2-苯基-4,4A,6,7,8,8A-六氢吡喃并[5,6-d][1,3]二恶英-7-基]乙酰胺
反应条件
1: NaOMe / methanol / 1 h / Ambient temperature 2: 33.5 g / p-TsOH*H2O / acetonitrile / 14 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 53, # 16 p. 5863 - 5876
→
反应条件
13343-61-8 N-[(4aR,6R,7R,8R,8aS)-6-苄氧基-8-羟基-2-苯基-4,4A,6,7,8,8A-六氢吡喃并[5,6-d][1,3]二恶英-7-基]乙酰胺
反应条件
1: 61 percent / 4 Angstroem molecular sieves, SnCl4 / acetonitrile / 14 h / 75 °C 2: NaOMe / methanol / 1 h / Ambient temperature 3: 33.5 g / p-TsOH*H2O / acetonitrile / 14 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 53, # 16 p. 5863 - 5876
→
反应条件
13343-61-8 N-[(4aR,6R,7R,8R,8aS)-6-苄氧基-8-羟基-2-苯基-4,4A,6,7,8,8A-六氢吡喃并[5,6-d][1,3]二恶英-7-基]乙酰胺
反应条件
1: 61 percent / 4 Angstroem molecular sieves, SnCl4 / acetonitrile / 14 h / 75 °C 2: NaOMe / methanol / 1 h / Ambient temperature 3: 33.5 g / p-TsOH*H2O / acetonitrile / 14 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 53, # 16 p. 5863 - 5876
→
反应条件
13343-61-8 N-[(4aR,6R,7R,8R,8aS)-6-苄氧基-8-羟基-2-苯基-4,4A,6,7,8,8A-六氢吡喃并[5,6-d][1,3]二恶英-7-基]乙酰胺
反应条件
1: 26 percent / Hg(CN)2, HgBr2 2: 6.88 g / NaOMe / methanol / Ambient temperature 3: p-toluenesulphonic acid / acetonitrile / 60 h / 60 °C View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 70, # 10 p. 2607 - 2617
13343-61-8 N-[(4aR,6R,7R,8R,8aS)-6-苄氧基-8-羟基-2-苯基-4,4A,6,7,8,8A-六氢吡喃并[5,6-d][1,3]二恶英-7-基]乙酰胺
→
反应条件
反应条件
1: NaH / tetrahydrofuran 2: NaCNBH3, molecular sieves 3 Angstroem, etheral HCl / tetrahydrofuran / 0.75 h View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 70, # 10 p. 2607 - 2617
13343-61-8 N-[(4aR,6R,7R,8R,8aS)-6-苄氧基-8-羟基-2-苯基-4,4A,6,7,8,8A-六氢吡喃并[5,6-d][1,3]二恶英-7-基]乙酰胺 +
→
反应条件
反应条件
sodium hydride in tetrahydrofuran
参考文献
Lee, Ho Huat; Congson, Ligaya N.; Whitfield, Dennis M.; Radics, Lajos R.; Krepinsky, Jiri J.
Canadian Journal of Chemistry, 1992 , vol. 70, # 10 p. 2607 - 2617