4-溴-2-(2,6-二氯苯基)-1H-咪唑并[4,5-c]吡啶合成路线 （共 6 条）
反应条件
1: With phosphorus oxytribromide T=70 - 110°C; 3 h; 2: With sodium carbonate in water T=20°C; pH=7; Cooling with ice;
参考文献
F. HOFFMANN-LA ROCHE AG; LAI, Yingjie; LIANG, Jun; MAGNUSON, Steven R.; TSUI, Vickie H.; ZHANG, Birong; ROBARGE, Kirk
Patent: WO2011/113802 A2, 2011 ;
Location in patent: Page/Page column 104 ;
WO 2011/113802 A2
反应条件
1: With hydrogen bromide; acetic acid T=90°C; 2: With potassium carbonate in water T=20°C; pH=7; Cooling with ice; Product distribution / selectivity;
参考文献
F. HOFFMANN-LA ROCHE AG; LAI, Yingjie; LIANG, Jun; MAGNUSON, Steven R.; TSUI, Vickie H.; ZHANG, Birong; ROBARGE, Kirk
Patent: WO2011/113802 A2, 2011 ;
Location in patent: Page/Page column 103-104 ;
WO 2011/113802 A2
反应条件
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane; acetonitrile / 0 - 23 °C 1.2: 120 °C 1.3: pH 7 2.1: hydrogen bromide; acetic acid / 90 °C 2.2: 20 °C / pH 7 / Cooling with ice View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; LAI, Yingjie; LIANG, Jun; MAGNUSON, Steven R.; TSUI, Vickie H.; ZHANG, Birong; ROBARGE, Kirk
Patent: WO2011/113802 A2, 2011 ;
WO 2011/113802 A2
反应条件
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane; acetonitrile / 0 - 23 °C 1.2: 120 °C 1.3: pH 7 2.1: hydrogen bromide; acetic acid / 90 °C 2.2: 20 °C / pH 7 / Cooling with ice View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; LAI, Yingjie; LIANG, Jun; MAGNUSON, Steven R.; TSUI, Vickie H.; ZHANG, Birong; ROBARGE, Kirk
Patent: WO2011/113802 A2, 2011 ;
WO 2011/113802 A2
反应条件
1.1: ammonium acetate / ethanol / 72 h / 75 °C 2.1: hydrogen bromide; acetic acid / 90 °C 2.2: 20 °C / pH 7 / Cooling with ice View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; LAI, Yingjie; LIANG, Jun; MAGNUSON, Steven R.; TSUI, Vickie H.; ZHANG, Birong; ROBARGE, Kirk
Patent: WO2011/113802 A2, 2011 ;
WO 2011/113802 A2
反应条件
1.1: polyphosphoric acid / 3 h / 190 °C 1.2: 20 °C / Cooling with ice 2.1: phosphorus oxytribromide / 3 h / 70 - 110 °C 2.2: 20 °C / pH 7 / Cooling with ice View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; LAI, Yingjie; LIANG, Jun; MAGNUSON, Steven R.; TSUI, Vickie H.; ZHANG, Birong; ROBARGE, Kirk
Patent: WO2011/113802 A2, 2011 ;
WO 2011/113802 A2
