1: platinum (II) chloride / toluene / 80 °C 2: boron tribromide View Scheme

1.1: (1,2,3,4,5-pentaphenylferrocen-1'-yl)-di-tert-butylphosphine; bis(dibenzylideneacetone)-palladium(0) / tetrahydrofuran / 20 °C / Inert atmosphere 2.1: sodium hydroxide / ethanol; water / 1 h / Reflux 3.1: methanesulfonic acid / 1 h / 50 °C 4.1: pyridine / dichloromethane / 0.17 h / 20 °C 4.2: -78 - 20 °C 5.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere 6.1: methanol; potassium carbonate / tetrahydrofuran / 1 h / 20 °C 7.1: platinum (II) chloride / toluene / 80 °C 8.1: boron tribromide View Scheme

1.1: sodium hydroxide / ethanol; water / 1 h / Reflux 2.1: methanesulfonic acid / 1 h / 50 °C 3.1: pyridine / dichloromethane / 0.17 h / 20 °C 3.2: -78 - 20 °C 4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere 5.1: methanol; potassium carbonate / tetrahydrofuran / 1 h / 20 °C 6.1: platinum (II) chloride / toluene / 80 °C 7.1: boron tribromide View Scheme

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere 2: methanol; potassium carbonate / tetrahydrofuran / 1 h / 20 °C 3: platinum (II) chloride / toluene / 80 °C 4: boron tribromide View Scheme

1.1: methanesulfonic acid / 1 h / 50 °C 2.1: pyridine / dichloromethane / 0.17 h / 20 °C 2.2: -78 - 20 °C 3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere 4.1: methanol; potassium carbonate / tetrahydrofuran / 1 h / 20 °C 5.1: platinum (II) chloride / toluene / 80 °C 6.1: boron tribromide View Scheme

1.1: palladium diacetate; potassium carbonate; triphenylphosphine / ethylene glycol dimethyl ether; water / 20 °C / Inert atmosphere 1.2: 23 h / Inert atmosphere; Reflux 2.1: (1,2,3,4,5-pentaphenylferrocen-1'-yl)-di-tert-butylphosphine; bis(dibenzylideneacetone)-palladium(0) / tetrahydrofuran / 20 °C / Inert atmosphere 3.1: sodium hydroxide / ethanol; water / 1 h / Reflux 4.1: methanesulfonic acid / 1 h / 50 °C 5.1: pyridine / dichloromethane / 0.17 h / 20 °C 5.2: -78 - 20 °C 6.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere 7.1: methanol; potassium carbonate / tetrahydrofuran / 1 h / 20 °C 8.1: platinum (II) chloride / toluene / 80 °C 9.1: boron tribromide View Scheme

1: sodium; amyl alcohol 2: HF 3: palladium; 1-methyl-naphthalene View Scheme

palladium; 1-methyl-naphthalene

1: HF 2: palladium; 1-methyl-naphthalene View Scheme

HepG2 cells; tris(hydroxymethyl)methylamine hydrochloride; dimethyl sulfoxide; magnesium chloride in water 72 h; Product distribution; Further Variations:Reagents;