(R)-4-甲酰基-2,2-二甲基噁唑啉-3-羧酸苄酯合成路线 （共 5 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=-15 - 0°C; 0.5 h; 2: With potassium hydrogensulfate; water in tetrahydrofuran T=0°C;
参考文献
GENZYME CORPORATION
Patent: WO2008/150486 A2, 2008 ;
Location in patent: Page/Page column 97-98 ;
WO 2008/150486 A2
反应条件
diisobutylaluminium hydride in toluene T=-78°C; Reduction; 2 h;
参考文献
Zhao; Qiao; Rong; Kozikowski
Tetrahedron Letters, 2000 , vol. 41, # 45 p. 8711 - 8715
反应条件
1: BF3*Et2O / acetone 2: NaBH4 / tetrahydrofuran; methanol 3: 87 percent / aq. NaClO; TEMPO; NaBr / ethyl acetate; toluene / 0.25 h / 0 °C View Scheme
参考文献
Zhao; Qiao; Rong; Kozikowski
Tetrahedron Letters, 2000 , vol. 41, # 45 p. 8711 - 8715
反应条件
1: aq. NaHCO3 / ethyl acetate 2: BF3*Et2O / acetone 3: NaBH4 / tetrahydrofuran; methanol 4: 87 percent / aq. NaClO; TEMPO; NaBr / ethyl acetate; toluene / 0.25 h / 0 °C View Scheme
参考文献
Zhao; Qiao; Rong; Kozikowski
Tetrahedron Letters, 2000 , vol. 41, # 45 p. 8711 - 8715
反应条件
1.1: LDA; HMPA / tetrahydrofuran / -78 °C
1.2: 80 percent / Ac2O; DMAP; pyridine
2.1: 90 percent / H2 / Pd/C / methanol
3.1: 92 percent / BiBr3 / acetonitrile; H2O / 8 h / 20 °C
4.1: 92 percent / TEMPO; NaClO2; NaClO / acetonitrile; aq. phosphate buffer / 18 h / 40 °C / pH 6.7
View Scheme
参考文献
Jiang, Sheng; Li, Peng; Lai, Christopher C.; Kelley, James A.; Roller, Peter P.
Journal of Organic Chemistry, 2006 , vol. 71, # 19 p. 7307 - 7314
