N5-(氨基硫代甲酰)-N2-[(1,1-二甲基乙氧基)羰基]-L-鸟氨酸叔丁酯合成路线 （共 6 条）
反应条件
1: With calcium carbonate in chloroform; water Addition; 16 h; 2: With ammonia in methanol T=0°C; Substitution; 3 h;
参考文献
Ulhaq, Saraj; Chinje, Edwin C.; Naylor, Matthew A.; Jaffar, Mohammed; Stratford, Ian J.; Threadgill, Michael D.
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 9 p. 1787 - 1796
反应条件
1.1: H2SO4 / dioxane / 6 h / 0 °C 2.1: 82 percent / Et3N / dioxane; H2O / 5 h 3.1: 77 percent / H2 / Pd/C / ethanol / 48 h 4.1: CaCO3 / CHCl3; H2O / 16 h 4.2: 89 percent / NH3 / methanol / 3 h / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 9 p. 1787 - 1796
反应条件
1.1: 82 percent / Et3N / dioxane; H2O / 5 h 2.1: 77 percent / H2 / Pd/C / ethanol / 48 h 3.1: CaCO3 / CHCl3; H2O / 16 h 3.2: 89 percent / NH3 / methanol / 3 h / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 9 p. 1787 - 1796
反应条件
1.1: CuCO3; Na2CO3 2.1: H2SO4 / dioxane / 6 h / 0 °C 3.1: 82 percent / Et3N / dioxane; H2O / 5 h 4.1: 77 percent / H2 / Pd/C / ethanol / 48 h 5.1: CaCO3 / CHCl3; H2O / 16 h 5.2: 89 percent / NH3 / methanol / 3 h / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 9 p. 1787 - 1796
反应条件
1.1: 77 percent / H2 / Pd/C / ethanol / 48 h 2.1: CaCO3 / CHCl3; H2O / 16 h 2.2: 89 percent / NH3 / methanol / 3 h / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 7, # 9 p. 1787 - 1796
反应条件
1: acetonitrile / 16 h / 23 °C 2: NaHCO3 / dioxane; H2O / 12 h / 23 °C 3: 90 percent / triethylamine, AgNO3 / acetonitrile / 2 h / 0 °C 4: 89 percent / H2 / 10percent Pd/C / methanol / 0.5 h / 760 Torr 5: 83 percent / HCl / dioxane / 20 h / 23 °C View Scheme
参考文献
Feldman
Tetrahedron Letters, 1991 , vol. 32, # 7 p. 875 - 878
