(4-异-丁氧基苯基)乙酸合成路线 （共 2 条）
反应条件
1: methyl [4-hydroxyphenyl]acetate With potassium carbonate in DMF (N,N-dimethyl-formamide) T=20°C; 1 h; 2: 2-methyl-1-bromopropane in DMF (N,N-dimethyl-formamide) T=80°C; 72 h; 3: With hydrogenchloride; potassium hydroxide more than 3 stages;
参考文献
ACADIA PHARMACEUTICALS INC.
Patent: WO2004/808 A2, 2003 ;
Location in patent: Page 37-38 ;
WO 2004/000808 A2
反应条件
1.1: K2CO3 / dimethylformamide / 0.5 h / 20 °C 1.2: dimethylformamide / 20 - 50 °C 2.1: 82 percent / aq. NaOH / ethanol / 20 °C View Scheme
参考文献
Gattrell, William T.; Sambrook Smith, Colin P.; Smith, Alun J.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 7 p. 2464 - 2469
