(S)-2,2-二甲基-4-乙烯基噁唑啉-3-羧酸叔丁酯合成路线 （共 18 条）
反应条件
1: Methyltriphenylphosphonium bromide With potassium hexamethylsilazane in tetrahydrofuran; toluene T=20°C; 1 h; 2: 1,1-Dimethylethyl (R)-4-formyl-2,2-dimethyl-3-oxazolidinecarboxylate in tetrahydrofuran; toluene T=20°C; 3.5 h;
参考文献
Keyes, Robert F.; Carter, Justin J.; Zhang, Xiaolin; Ma, Zhenkun
Organic Letters, 2005 , vol. 7, # 5 p. 847 - 849
反应条件
sodium hexamethyldisilazane in tetrahydrofuran Wittig reaction;
参考文献
Takahata, Hiroki; Banba, Yasunori; Ouchi, Hidekazu; Nemoto, Hideo; Kato, Atsushi; Adachi, Isao
Journal of Organic Chemistry, 2003 , vol. 68, # 9 p. 3603 - 3607
反应条件
RuCl(Ph3P)3; triphenylphosphine in tetrahydrofuran; isopropyl alcohol T=25°C; 4 h; Title compound not separated from byproducts;
参考文献
Angewandte Chemie - International Edition, , vol. 40, # 15 p. 2887 - 2890
反应条件
in various solvent(s) T=175 - 180°C; 6 h;
参考文献
Ravi Kumar, Jalluri S.; Datta, Apurba
Tetrahedron Letters, 1997 , vol. 38, # 38 p. 6779 - 6780
反应条件
boron trifluoride diethyl etherate in acetone T=-20 - 20°C; Condensation;
参考文献
Organic Letters, , vol. 2, # 8 p. 1089 - 1091
反应条件
trimethylaluminum; zinc in tetrahydrofuran 12 h; Ambient temperature;
参考文献
Moriwake, Toshio; Hamano, Shin-ichi; Saito, Seiki; Torii, Sigeru
Chemistry Letters, 1987 , p. 2085 - 2088
反应条件
1: 2.1 g / NaHCO3 / methanol; ethyl acetate; H2O / biphasic 2: 48 percent / Pseudomonas cepecia (Amano PS-30) lipase / CH2Cl2 / 20 °C / Enzymatic reaction 3: 96 percent / KCN / methanol / 20 °C 4: BF3*Et2O / acetone / -20 - 20 °C View Scheme
参考文献
Organic Letters, , vol. 2, # 8 p. 1089 - 1091
反应条件
1: 48 percent / Pseudomonas cepecia (Amano PS-30) lipase / CH2Cl2 / 20 °C / Enzymatic reaction 2: 96 percent / KCN / methanol / 20 °C 3: BF3*Et2O / acetone / -20 - 20 °C View Scheme
参考文献
Organic Letters, , vol. 2, # 8 p. 1089 - 1091
反应条件
1: 96 percent / KCN / methanol / 20 °C 2: BF3*Et2O / acetone / -20 - 20 °C View Scheme
参考文献
Organic Letters, , vol. 2, # 8 p. 1089 - 1091
反应条件
1: 93 percent / BF3OEt2 / acetone / 12 h / Ambient temperature 2: 78 percent / DIBAL-H / toluene / 1.5 h / -78 °C 3: 75 percent / AlMe3, Zn / tetrahydrofuran / 12 h / Ambient temperature View Scheme
参考文献
Chemistry Letters, , p. 2085 - 2088
