(S)-2,2-二甲基-4-乙烯基噁唑啉-3-羧酸叔丁酯合成路线 （共 18 条）
反应条件
in tetrahydrofuran; hexane T=25°C; 4 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 56, # 13 p. 4196 - 4204
反应条件
1: 95 percent / BF3*Et2O / acetone / Ambient temperature 2: 93 percent / NaIO4, NaHCO3 / methanol; H2O / 0 °C 3: 69 percent / various solvent(s) / 6 h / 175 - 180 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 38, # 38 p. 6779 - 6780
反应条件
1: 93 percent / NaIO4, NaHCO3 / methanol; H2O / 0 °C 2: 69 percent / various solvent(s) / 6 h / 175 - 180 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 38, # 38 p. 6779 - 6780
反应条件
1: 78 percent / DIBAL-H / toluene / 1.5 h / -78 °C 2: 75 percent / AlMe3, Zn / tetrahydrofuran / 12 h / Ambient temperature View Scheme
参考文献
Chemistry Letters, , p. 2085 - 2088
反应条件
1: OsO4, NMO / acetone / Ambient temperature 2: NaIO4, SiO2 / CH2Cl2 / Ambient temperature View Scheme
参考文献
Ravi Kumar, Jalluri S.; Datta, Apurba
Tetrahedron Letters, 1997 , vol. 38, # 38 p. 6779 - 6780
反应条件
1: 1.) 9-borabicyclo<3.3.1>nonane, 2.) aq. H2O2, NaOH / 1.) THF, RT, 12 h, 2.) THF, RT, 4 h 2: Des-Martin periodinane / CH2Cl2 / 0.3 h / Ambient temperature View Scheme
参考文献
Kawate, Tomohiko; Fukuta, Natsuko; Nishida, Atsushi; Nakagawa, Masako
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 12 p. 2116 - 2118
反应条件
sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide 1.) THF, RT, 12 h, 2.) THF, RT, 4 h; Multistep reaction;
参考文献
Kawate, Tomohiko; Fukuta, Natsuko; Nishida, Atsushi; Nakagawa, Masako
Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 12 p. 2116 - 2118
反应条件
toluene-4-sulfonic acid in methanol
T=0 - 20°C;
参考文献
Incyte Corporation; Li, Yun-Long; Zhu, Wenyu; Mei, Song; Glenn, Joseph
Patent: US2014/121198 A1, 2014 ;
Location in patent: Paragraph 0645; 0647 ;
