1: 84 percent / pyridine / cyclohexane; dioxane / Ambient temperature 2: 91 percent / xylene / 2 h / Heating 3: 42 percent / sodium hydride / dimethylformamide / 140 °C 4: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, 2 h 5: 89 percent / trifluoroacetic acid / 1.5 h / Ambient temperature 6: 1.) NaH / 1.) DMF, 2.) DMF View Scheme

1: 84 percent / pyridine / cyclohexane; dioxane / Ambient temperature 2: 91 percent / xylene / 2 h / Heating 3: 42 percent / sodium hydride / dimethylformamide / 140 °C 4: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, 2 h 5: 89 percent / trifluoroacetic acid / 1.5 h / Ambient temperature 6: 1.) NaH / 1.) DMF, 2.) DMF View Scheme

1: 42 percent / sodium hydride / dimethylformamide / 140 °C 2: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, 2 h 3: 89 percent / trifluoroacetic acid / 1.5 h / Ambient temperature 4: 1.) NaH / 1.) DMF, 2.) DMF View Scheme

sodium hydride 1.) DMF, 2.) DMF; Multistep reaction;

1: 89 percent / trifluoroacetic acid / 1.5 h / Ambient temperature 2: 1.) NaH / 1.) DMF, 2.) DMF View Scheme