2-氯-N-(2-氯-4-甲基吡啶-3-基)烟酰胺合成路线 （共 10 条）
反应条件
in dichloromethane 1.) -78 deg C, 1 h, 2.) RT, 23 h;
参考文献
Norman; Minick; Martin
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 3 p. 771 - 779
反应条件
pyridine in 1,4-dioxane; dichloromethane; cyclohexane
反应条件
1: 98 percent / SnCl2 * 2 H2O, conc. HCl / diethyl ether / 0.33 h / Ambient temperature 2: 87 percent / CH2Cl2 / 1.) -78 deg C, 1 h, 2.) RT, 23 h View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 30, # 3 p. 771 - 779
反应条件
1: 99 percent / thionyl chloride / 1 h / Heating 2: 87 percent / CH2Cl2 / 1.) -78 deg C, 1 h, 2.) RT, 23 h View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 30, # 3 p. 771 - 779
参考文献
Journal of Heterocyclic Chemistry, , vol. 30, # 3 p. 771 - 779
反应条件
1: xylene / Heating 2: NaH / various solvent(s) / Heating 3: 1.) NaH / 1.) DMSO, 2.) DMSO View Scheme
参考文献
Hargrave, Karl D.; Proudfoot, John R.; Grozinger, Karl G.; Cullen, Ernest; Kapadia, Suresh R.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2231 - 2241
反应条件
1: xylene / Heating 2: NaH / various solvent(s) / Heating View Scheme
参考文献
Hargrave, Karl D.; Proudfoot, John R.; Grozinger, Karl G.; Cullen, Ernest; Kapadia, Suresh R.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2231 - 2241
反应条件
1: With CaO in diethylene glycol dimethyl ether T=135 - 145°C; 2: With sodium hydride T=140°C; 0.5 - 1 h; 3: With water; acetic acid; ethyl acetate T=0 - 10°C; 1 - 2 h;
参考文献
DR. REDDY'S LABORATORIES LIMITED; DR. REDDY'S LABORATORIES INC.
Patent: US2005/59653 A1, 2005 ;
Location in patent: Page/Page column 3 ;
反应条件
in ethanol; diethylene glycol dimethyl ether; cyclohexane; water; acetic acid
参考文献
Boehringer Ingelheim KG
Patent: US5569760 A1, 1996 ;
反应条件
1: 94 percent / 4 h / 140 °C 2: 67 percent / 80percent NaH / bis-(2-methoxy-ethyl) ether / 1.5 h / 185 °C View Scheme
参考文献
Hargrave, Karl D.; Proudfoot, John R.; Grozinger, Karl G.; Cullen, Ernest; Kapadia, Suresh R.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2231 - 2241
