N-(2-氯-4-甲基-3-吡啶)-2-环丙氨基-3-吡啶甲酰胺合成路线 （共 9 条）
反应条件
in toluene T=125 - 130°C; P=775.743 Torr; 21 h;
参考文献
WO2007/10352 A1, ;
Page/Page column 20 ;
参考文献
Journal of Heterocyclic Chemistry, , vol. 30, # 3 p. 771 - 779
反应条件
potassium phosphate in acetonitrile T=50°C; 20 h;
参考文献
US2004/2603 A1, ;
Page 4 ;
反应条件
1: 2-(cyclopropylamino)pyridine-3-carboxylic acid With thionyl chloride 0.533333 h; Heating / reflux; 2: 2-Chloro-3-amino-4-methylpyridine in acetonitrile T=50°C; 3: With potassium phosphate in acetonitrile T=50°C; 16 h;
参考文献
US2004/2603 A1, ;
Page 5 ;
反应条件
1: 98 percent / SnCl2 * 2 H2O, conc. HCl / diethyl ether / 0.33 h / Ambient temperature 2: 87 percent / CH2Cl2 / 1.) -78 deg C, 1 h, 2.) RT, 23 h 3: 94 percent / 4 h / 140 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 30, # 3 p. 771 - 779
反应条件
1: 87 percent / CH2Cl2 / 1.) -78 deg C, 1 h, 2.) RT, 23 h 2: 94 percent / 4 h / 140 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 30, # 3 p. 771 - 779
反应条件
1: 87 percent / CH2Cl2 / 1.) -78 deg C, 1 h, 2.) RT, 23 h 2: 94 percent / 4 h / 140 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 30, # 3 p. 771 - 779
反应条件
1: 99 percent / thionyl chloride / 1 h / Heating 2: 87 percent / CH2Cl2 / 1.) -78 deg C, 1 h, 2.) RT, 23 h 3: 94 percent / 4 h / 140 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 30, # 3 p. 771 - 779
反应条件
1: With potassium tert-butylate in diethylene glycol dimethyl ether T=100 - 110°C; 1.5 h; 2: With acetic acid in diethylene glycol dimethyl ether T=5 - 10°C; pH=6.0 - 7.0; Product distribution / selectivity;
参考文献
EMCURE PHARMACEUTICALS LIMITED
Patent: WO2007/10352 A1, 2007 ;
Location in patent: Page/Page column 20-21 ;
