piperidine in methanol 72 h;

1: imidazole / dimethylformamide / 18 h / 25 °C 2: 1.) aq. H2O2, 1N NaOH, 2.) aluminum amalgam / 1.) methanol, -10-0 deg C, 2 h 3: 83 percent / morphilinosulfotrifluoride / CH2Cl2 / 1 h / -78 °C 4: 75 percent / aq. acetic acid, 1N HCl / tetrahydrofuran / 30 h / 25 °C 5: alkaline medium View Scheme

1: 1.) aq. H2O2, 1N NaOH, 2.) aluminum amalgam / 1.) methanol, -10-0 deg C, 2 h 2: 83 percent / morphilinosulfotrifluoride / CH2Cl2 / 1 h / -78 °C 3: 75 percent / aq. acetic acid, 1N HCl / tetrahydrofuran / 30 h / 25 °C 4: alkaline medium View Scheme

1: 83 percent / morphilinosulfotrifluoride / CH2Cl2 / 1 h / -78 °C 2: 75 percent / aq. acetic acid, 1N HCl / tetrahydrofuran / 30 h / 25 °C 3: alkaline medium View Scheme

1: 75 percent / aq. acetic acid, 1N HCl / tetrahydrofuran / 30 h / 25 °C 2: alkaline medium View Scheme