(R)-(+)-3-甲基环己酮合成路线 （共 64 条）
参考文献
Weber, Edwin; Wimmer, Claus; Llamas-Saiz, Antonio L.; Foces-Foces, Concepcion
Journal of the Chemical Society, Chemical Communications, 1992 , # 10 p. 733 - 735
反应条件
hydrogenchloride; water 8 h; Reflux;
参考文献
Santos Pisoni, Diego dos; Sobieski da Costa, Jesse; Gamba, Douglas; Petzhold, Cesar Liberato; Cesar de Amorim Borges, Antonio; Ceschi, Marco Antonio; Lunardi, Paula; Saraiva Goncalves, Carlos Alberto
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 2 p. 526 - 535
反应条件
(CuOTf)2.C6H6; [(2-PPh2)C6H4CH]-Val-Phe-NH-Bu in toluene T=-30°C; 12 h;
参考文献
Degrado; Mizutani; Hoveyda
Journal of the American Chemical Society, 2001 , vol. 123, # 4 p. 755 - 756
反应条件
tetrafluoroboric acid; hydrogen; ruthenium catalyst with atropoisomeric (R)-ligand in water; isopropyl alcohol T=60°C; Catalytic hydrogenation; P=45003.6 Torr; 20 h; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 64, # 16 p. 5768 - 5776
反应条件
n-butyllithium; chiral dihydroimidazolium salt; copper(II) bis(trifluoromethanesulfonate) in diethyl ether; hexane T=20°C; 3 h;
参考文献
Journal of Organometallic Chemistry, , vol. 690, # 23 p. 5237 - 5254
反应条件
NADPH; aq. Bis-Tris-buffer in octane T=60°C; pH=6; 10.4 h; electroenzymatic reduction;
参考文献
Hoellrigl, Volker; Otto, Katja; Schmid, Andreas
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 8-9 p. 1337 - 1340
反应条件
hydrogen; HRuCl(TBPC)2 in benzene T=80°C; P=30400 Torr; 22 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organometallic Chemistry, , vol. 327, p. 269 - 274
反应条件
1: With L-Selectridereg; in tetrahydrofuran T=20°C; 0.5 h; Inert atmosphere; 2: With sulfuric acid in tetrahydrofuran; water Cooling;
参考文献
Denmark, Scott E.; Ares, Jeffrey J.
Journal of Organic Chemistry, 2008 , vol. 73, # 24 p. 9647 - 9656
反应条件
(R)-DTBM-Segphos; [Cu(PPh3)2NO3]; hydrogen; sodium t-butanolate in isopropyl alcohol T=30°C; P=37503.8 Torr; 18 h; optical yield given as percent eeenantioselective reaction;
参考文献
Shimizu, Hideo; Nagano, Takuto; Sayo, Noboru; Saito, Takao; Ohshima, Takashi; Mashima, Kazushi
Synlett, 2009 , # 19 p. 3143 - 3146
反应条件
multistep reactions; various solvents and temperatures; also with n-BuLi, t-BuLi, and PhLi; Product distribution;
参考文献
Journal of Organic Chemistry, , vol. 60, # 4 p. 903 - 909
