(R)-(+)-3-甲基环己酮合成路线 （共 64 条）
反应条件
sulfuric acid; 1-hexadecylpyridinium chloride in water 2 h; Reflux;
参考文献
Vashchenko, Elena V.; Knyazeva, Irina V.; Krivoshey, Alexander I.; Vashchenko, Valerii V.
Monatshefte fur Chemie, 2012 , vol. 143, # 11 p. 1545 - 1549
反应条件
1: With sodium hydroxide in water T=20°C; 24 h; 2: With sodium periodate in water T=20°C; 1 h; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 70, # 17 p. 6639 - 6646
反应条件
1: With potassium phosphate buffer; Rhodotorula glutinis ATCC 201718 hydrolase T=35°C; pH=8.0; 6 h; 2: With sodium periodate in water T=20°C; 1 h; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 70, # 17 p. 6639 - 6646
反应条件
glucose dehydrogenase; D-glucose; enoate-reductase YQJm from Bacillus subtilis mutant C26D/A104F; nicotinamide adenine dinucleotide phosphate T=30°C; pH=7; 5 h; aq. phosphate bufferEnzymatic reaction; optical yield given as percent ee;
参考文献
Advanced Synthesis and Catalysis, , vol. 351, # 18 p. 3287 - 3305
反应条件
lt;(S)-2-(methoxymethyl)pyrolidinogt;cuprate in diethyl ether T=-25°C; asymmetric induction with other chiral heterocuprates, other solvents and at various temperature; Product distribution;
参考文献
Journal of the American Chemical Society, , vol. 109, p. 2040
反应条件
[Cu(I)(CH3CN)4]PF6; 1,1'-binaphthalene-based chiral ligand in diethyl ether T=-45°C; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 16, # 19 p. 3143 - 3146
反应条件
1: methyllithium With copper (I) cyanide; lithium bromide in diethyl ether T=-78°C; 0.5 h; 2: With chloro-trimethyl-silane in diethyl ether 3: (+)-(2S)-N-[cyclohex-2-en-1-yliden]-2-(methoxymethyl)pyrrolidin-1-amine optical yield given as percent eeenantioselective reactionFurther stages;
参考文献
Advanced Synthesis and Catalysis, , vol. 352, # 13 p. 2281 - 2290
反应条件
n-butyllithium; (4R,5R)-5-[(methoxy)(diphenyl)methyl]-2,2-dimethyl-α,α-diphenyl-1,3-dioxolane-4-methanethiol; copper(l) chloride in tetrahydrofuran T=-78°C; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Helvetica Chimica Acta, , vol. 95, # 8 p. 1239 - 1272
参考文献
Bulletin de la Societe Chimique de France, , vol. <4> 53, p. 170,175
反应条件
1: With diphenyl-N,N-bis-((S,S)-1-naphthalen-2-yl-ethyl)phosphinamine; copper(ll) bromide in diethyl ether T=-30°C; 3 h; 2: With ammonium chloride in diethyl ether; water optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 20, # 24 p. 2866 - 2870
