(R)-(+)-3-甲基环己酮合成路线 （共 64 条）
反应条件
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Chelucci, Giorgio; Cossu, Sergio; Scano, Gianfranco; Soccolini, Francesco
Heterocycles, 1990 , vol. 31, # 8 p. 1397 - 1403
反应条件
1.1: TiCl4; Bu3N / CH2Cl2 / 0.5 h / -78 °C
1.2: 52 percent / CH2Cl2 / 14 h / 20 °C
2.1: LAH / propan-2-ol
View Scheme
参考文献
Tanabe, Yoo; Mitarai, Kumi; Higashi, Takahiro; Misaki, Tomonori; Nishii, Yoshinori
Chemical Communications, 2002 , # 21 p. 2542 - 2543
反应条件
1: With triethyloxonium tetra-fluoroborate in dichloromethane
2: With hydrogen bromide in methanol; water
T=60°C; 3.5 h; Further stages.;
参考文献
Fujita, Morifumi; Sakanishi, Yuichi; Nishii, Masayoshi; Yamataka, Hiroshi; Okuyama, Tadashi
Journal of Organic Chemistry, 2002 , vol. 67, # 23 p. 8130 - 8137
反应条件
1: triethyloxonium tetrafluoroborate / CH2Cl2
2: HBr / methanol; H2O / 3.5 h / 60 °C
View Scheme
参考文献
Fujita, Morifumi; Sakanishi, Yuichi; Nishii, Masayoshi; Yamataka, Hiroshi; Okuyama, Tadashi
Journal of Organic Chemistry, 2002 , vol. 67, # 23 p. 8130 - 8137
反应条件
potassium hydroxide in methanol; diethyl ether
参考文献
Lightner,D.A.; Docks,E.L.
Tetrahedron, 1979 , vol. 35, p. 713 - 720
参考文献
Djerassi; Krakower
Journal of the American Chemical Society, 1959 , vol. 81, p. 237,242
反应条件
1: hydrazine hydrate
2: sodium; alcohol
3: hydrochloric acid
View Scheme
参考文献
Kishner
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1907 , vol. 39, p. 1242
Chem. Zentralbl., 1908 , vol. 79, # I p. 1177
反应条件
1: benzene / 24 h / Heating
2: 68 percent / benzene / 3 h / 0 °C
View Scheme
参考文献
Smale
Tetrahedron Letters, 1984 , vol. 25, # 27 p. 2913 - 2914
反应条件
1: 1.) LDA; 2.) MCPBA / 1.) THF, - 78 deg C; 2.) CH2Cl2, -78 deg C
2: 1.) LDA, HMPT / 1.) THF, - 35 deg C, 3h; 2.) THF, - 35 deg C. 2h
View Scheme
参考文献
Walts; Roush
Tetrahedron, 1985 , vol. 41, # 17 p. 3463 - 3478
反应条件
3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide
1.) THF, - 78 deg C; 2.) CH2Cl2, -78 deg C; Yield given. Multistep reaction;
参考文献
Roush; Walts
Journal of the American Chemical Society, 1984 , vol. 106, # 3 p. 721 - 723
