1: C8H5Br2NO3 With tetrabutyl ammonium fluoride in N,N-dimethyl-formamide T=20°C; 4 h; Sealed tubeInert atmosphere; 2: benzenesulphinic acid sodium salt With copper diacetate; triethylamine; palladium dichloride in N,N-dimethyl-formamide T=110°C; 12 h; Sealed tubeInert atmosphere;

tetrabutyl ammonium fluoride; palladium diacetate; triphenylphosphine in 1-methyl-pyrrolidin-2-one T=80°C; tandem elimination-addition-Hiyama coupling; 12 h;