4'-氨甲基-2-氰基联苯合成路线 （共 10 条）
反应条件
triphenylphosphine 2 h; Ambient temperature;
参考文献
Ashton; Cantone; Chang; Hutchins; Strelitz; MacCoss; Lotti; Faust; Chen; Bunting; Schorn; Kivlighn; Siegl
Journal of Medicinal Chemistry, 1993 , vol. 36, # 5 p. 591 - 609
反应条件
sodium azide in N,N-dimethyl-formamide T=30 - 40°C; 0.5 h;
参考文献
Huang, Horng-Chih; Reitz, David B.; Chamberlain, Timothy S.; Olins, Gillian M.; Corpus. Valerie M.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2172 - 2181
反应条件
triphenylphosphine in tetrahydrofuran; methanol; dichloromethane
参考文献
Merck and Co., Inc.
Patent: US5336778 A1, 1994 ;
US 5336778 A
反应条件
1: NBS, AIBN / CCl4 / Heating 2: NaN3 / dimethylformamide / 24 h / Ambient temperature 3: H2 / 10percent Pd/C / ethanol / 20 h / 2068.6 Torr View Scheme
参考文献
Huang, Horng-Chih; Reitz, David B.; Chamberlain, Timothy S.; Olins, Gillian M.; Corpus. Valerie M.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 15 p. 2172 - 2181
反应条件
in tetrahydrofuran; dichloromethane
参考文献
Merck and Co., Inc.
Patent: US5411980 A1, 1995 ;
US 5411980 A
反应条件
benzotriazol-1-ol; dicyclohexyl-carbodiimide in dichloromethane T=25 - 35°C;
参考文献
Satyanarayana, Bollikonda; Sumalatha, Yasareni; Sridhar, Chaganti; Venkatraman, Sundaram; Reddy, Padi Pratap
Heterocyclic Communications, 2006 , vol. 12, # 5 p. 323 - 328
反应条件
1: 96 percent / 1-hydroxybenzotriazole; dicyclohexyl carbodiimide / CH2Cl2 / 25 - 35 °C 2: 81 percent / trifluoro acetic acid / toluene / Heating 3: 95 percent / tributyl tin chloride; sodium azide / o-xylene / Heating View Scheme
参考文献
Ye, Ping; Sargent, Katie; Stewart, Ethan; Liu, Ji-Feng; Yohannes, Daniel; Yu, Libing
Journal of Organic Chemistry, 2006 , vol. 71, # 8 p. 3137 - 3140
反应条件
1: With methanesulfonic acid in toluene T=20°C; 48 h; Heating / reflux; 2: With sodium hydroxide in water; toluene 0.5 h; Product distribution / selectivity;
参考文献
ALEMBIC LIMITED
Patent: WO2007/49293 A1, 2007 ;
Location in patent: Page/Page column 17-18 ;
反应条件
1: 1-aminocyclopentanecarboxylic acid methyl ester hydrochloride; n-Pentanoic acid With tricresyl phosphate in pyridine T=150°C; 0.166667 h; microwave irradiation; 2: [(2'-cyanobiphenyl-4-yl)methyl]amine in pyridine T=250°C; P=7500.6 Torr; 0.166667 h; microwave irradiation;
参考文献
Ye, Ping; Sargent, Katie; Stewart, Ethan; Liu, Ji-Feng; Yohannes, Daniel; Yu, Libing
Journal of Organic Chemistry, 2006 , vol. 71, # 8 p. 3137 - 3140
反应条件
1: 96 percent / 1-hydroxybenzotriazole; dicyclohexyl carbodiimide / CH2Cl2 / 25 - 35 °C 2: 81 percent / trifluoro acetic acid / toluene / Heating View Scheme
参考文献
Satyanarayana, Bollikonda; Sumalatha, Yasareni; Sridhar, Chaganti; Venkatraman, Sundaram; Reddy, Padi Pratap
Heterocyclic Communications, 2006 , vol. 12, # 5 p. 323 - 328
