2-氨基-4-(羟基甲基)苯甲酸甲酯合成路线 （共 3 条）
反应条件
diisobutylaluminium hydride in tetrahydrofuran; diethyl ether T=-78 - 0°C; 4 h;
参考文献
Augeri, David J.; O'Connor, Stephen J.; Janowick, Dave; Szczepankiewicz, Bruce; Sullivan, Gerry; Larsen, John; Kalvin, Douglas; Cohen, Jerry; Devine, Edward; Zhang, Haichao; Cherian, Sajeev; Saeed, Badr; Ng, Shi-Chung; Rosenberg, Saul
Journal of Medicinal Chemistry, 1998 , vol. 41, # 22 p. 4288 - 4300
反应条件
1: With 4-methyl-morpholine; p-iodo-benzoic acid chloride in ethylene glycol dimethyl ether T=-15°C; 0.25 h; 2: With sodium tetrahydroborate in ethylene glycol dimethyl ether; water T=-15 - 20°C; 0.25 h; 3: With sodium hydroxide; water in ethylene glycol dimethyl ether
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2006/108591 A1, 2006 ;
Location in patent: Page/Page column 119 ;
WO 2006/108591 A1
反应条件
in N-methyl-acetamide; water
参考文献
Priepke, Henning; Hauel, Norbert; Damm, Klaus; Schnapp, Andreas
Patent: US2002/128495 A1, 2002 ;
