(3S,4s)-4-苄基-3-(3-甲基戊酰基)-噁唑啉-2-酮合成路线 （共 15 条）
反应条件
1: 92 percent / 1.) BuLi / tetrahydrofuran / 1.) -78 deg C
2: toluene; hexane / 0.8 h / -78 °C
View Scheme
参考文献
Rueck, Karola; Kunz, Horst
Synthesis, 1993 , # 10 p. 1018 - 1028
反应条件
in hexane; toluene
T=-78°C; 0.8 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Rueck, Karola; Kunz, Horst
Synthesis, 1993 , # 10 p. 1018 - 1028
反应条件
n-butyllithium
1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, a) from -78 deg C to 0 deg C, b) 0 deg C, 2 h; Yield givenMultistep reaction;
参考文献
Roeder, Michael; Spiegelstein, Ofer; Schurig, Volker; Bialer, Meir; Yagen, Boris
Tetrahedron Asymmetry, 1999 , vol. 10, # 5 p. 841 - 853
反应条件
in hexane; toluene
1.) -40 deg C, irradiation, 5 h; 2.) -40 deg C, 41 h, in the dark; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Rueck, Karola; Kunz, Horst
Synthesis, 1993 , # 10 p. 1018 - 1028
反应条件
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C
1.2: 0.5 h / -78 °C
2.1: dihydrogen peroxide; lithium hydroxide hydrate / tetrahydrofuran; water / 3 h / 0 - 20 °C
View Scheme
参考文献
Kawamura, Shuhei; Unno, Yuka; Asai, Akira; Arisawa, Mitsuhiro; Shuto, Satoshi
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 38 p. 6615 - 6622
