2-氯-5-苯基-1,3,4-噻二唑合成路线 （共 12 条）
反应条件
1: N2H4*H2O / ethanol 2: Py View Scheme
参考文献
Potts,K.T.; Huseby,R.M.
Journal of Organic Chemistry, 1966 , vol. 31, p. 3528 - 3531
反应条件
1: NaN3 / dimethylformamide 2: CHCl3 / Heating 3: aq. H2SO4 4: aq. HBr, AcOH / Heating View Scheme
参考文献
Tetrahedron, , vol. 24, p. 3209 - 3217
反应条件
hydrazine hydrate in ethanol 0.5 h; Heating;
参考文献
Carvalho, Samir A.; Da Silva, Edson F.; Santa-Rita, Ricardo M.; De Castro, Solange L.; Fraga, Carlos A.M.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 5967 - 5970
参考文献
Russo; Guccione; Santagati; Caruso; Leone; Attaguile; Roxas
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 5 p. 409 - 420
反应条件
hydrogenchloride; copper; sodium nitrite
T=-5 - 65°C;
参考文献
Shen, Hong C.; Ding, Fa-Xiang; Colletti, Steven L.
Organic Letters, 2006 , vol. 8, # 7 p. 1447 - 1450
反应条件
1: NH4Fe(SO4)2*12H2O
2: NaNO2; aq. HCl / Cu
View Scheme
参考文献
Foroumadi; Tabatabai; Gitinezhad; Zarrindast; Shafiee
Pharmacy and Pharmacology Communications, 2000 , vol. 6, # 1 p. 31 - 33
反应条件
in ethylene glycol dimethyl ether
参考文献
Gulf Research and Development Company
Patent: US3959301 A1, 1976 ;
反应条件
1: HCl / aq. ethanol
2: NH4Fe(SO4)2*12H2O
3: NaNO2; aq. HCl / Cu
View Scheme
参考文献
Foroumadi; Tabatabai; Gitinezhad; Zarrindast; Shafiee
Pharmacy and Pharmacology Communications, 2000 , vol. 6, # 1 p. 31 - 33
反应条件
1: POCl3
2: NaNO2; aq. HCl / Cu
View Scheme
参考文献
Foroumadi; Tabatabai; Gitinezhad; Zarrindast; Shafiee
Pharmacy and Pharmacology Communications, 2000 , vol. 6, # 1 p. 31 - 33
反应条件
triethylamine in 1,4-dioxane
70 h; Heating / reflux;
参考文献
NEUROSEARCH A/S
Patent: WO2004/29053 A1, 2004 ;
Location in patent: Page 23 ;
WO 2004/029053 A1
