(1S,2S)-反式-2-氨基环己醇合成路线 (共 15 条)
反应条件
1: 60 percent / tributyltin hydride, AIBN / toluene; methanol / 1 h / Heating 2: 73 percent / 6 M HCl / methanol / 0.5 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 655 - 661
反应条件
triethylamine in dichloromethane T=20°C; 2 h;
参考文献
ARRAY BIOPHARMA INC.; ANDREWS, Steven W.; CONDROSKI, Kevin Ronald; DE MEESE, Lisa A.; FELL, Jay Bradford; FISCHER, John P.; LE HUEROU, Yvan; JOSEY, John A.; KOCH, Kevin; MIKNIS, Gregory F.; RODRIGUEZ, Martha E.; TOPALOV, George T.; WALLACE, Eli M.; XU, Rui
Patent: WO2011/29027 A1, 2011 ;
Location in patent: Page/Page column 130; 131 ;
WO 2011/029027 A1
反应条件
sodium hydrogencarbonate in dichloromethane
参考文献
Merck and Co., Inc.
Patent: US6043358 A1, 2000 ;
反应条件
triethylamine in dichloromethane T=20°C; 2 h;
参考文献
ARRAY BIOPHARMA INC.; ANDREWS, Steven W.; CONDROSKI, Kevin Ronald; DE MEESE, Lisa A.; FELL, Jay Bradford; FISCHER, John P.; LE HUEROU, Yvan; JOSEY, John A.; KOCH, Kevin; MIKNIS, Gregory F.; RODRIGUEZ, Martha E.; TOPALOV, George T.; WALLACE, Eli M.; XU, Rui
Patent: WO2011/29027 A1, 2011 ;
Location in patent: Page/Page column 130; 131 ;
WO 2011/029027 A1
反应条件
sodium hydrogencarbonate in dichloromethane
参考文献
Merck and Co., Inc.
Patent: US6043358 A1, 2000 ;