2-[3-(R)-[3-[2-(7-氯-2-喹啉基)乙烯基]苯基]-3-羰基丙基]苯甲酸甲酯合成路线 (共 2 条)
反应条件
sodium formate; [(R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine](p-cymene)ruthenium; Aliquatreg; 336 in dichloromethane; water T=40°C; 60 h; Inert atmosphere; Product distribution / selectivity;
参考文献
DSM IP ASSETS B.V.; LEFORT, Laurent
Patent: WO2011/42416 A1, 2011 ;
Location in patent: Page/Page column 11 ;
反应条件
1: With borane-THF; (R)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c]-[1,3,2]oxazaborole in tetrahydrofuran; toluene T=10°C; 2.66667 h; 2: With hydrogenchloride in water T=20°C;
参考文献
CHEMAGIS LTD.
Patent: US2006/223999 A1, 2006 ;
Location in patent: Page/Page column 4 ;