顺式-4-羟基甲基环己烷-1-羧酸甲酯合成路线 （共 8 条）
反应条件
BH3*S(CH3)2 in tetrahydrofuran T=-78°C; 3.33333 h;
参考文献
US2012/165347 A1, ;
Page/Page column 43 ;
US 20120165347 A1
反应条件
sulfuric acid 2 h; Heating / reflux;
参考文献
WO2006/69196 A1, ;
Page/Page column 66 ;
WO 2006/069196 A1
反应条件
hydrogen; Raney nickel doped, 3wtpercent Re; Metalyste Alpha.(R). 9401 T=205 - 225°C; P=259341 Torr; Product distribution / selectivity;
参考文献
US6919489 B1, ;
Page column 12 ;
反应条件
hydrogen in methanol T=220°C; P=45004.5 Torr; Green chemistry;
参考文献
Green Chemistry, , vol. 15, # 9 p. 2389 - 2393
反应条件
1: water; Ba(OH)2 / methanol / 12 h / 25 °C 2: BH3*SMe2 / tetrahydrofuran / 3 h / 15 °C View Scheme
反应条件
sodium hydrogencarbonate; Dess-Martin periodane in dichloromethane
T=20°C; 2.5 h;
参考文献
ASTRAZENECA AB
Patent: US2012/165347 A1, 2012 ;
Location in patent: Page/Page column 44 ;
US 20120165347 A1
反应条件
triethylamine in dichloromethane; water
参考文献
The Wellcome Foundation Limited
Patent: US5116862 A1, 1992 ;
