1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 0.67 h / 100 °C / Sealed vial 2.1: 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / tetrachloromethane / 2 h / 100 °C 3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere 3.2: 1 h / 0 - 20 °C 4.1: sodium hydroxide / ethanol / 2 h / 100 °C 4.2: 20 °C / pH ~ 4 5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h 5.2: 0.5 h / 20 °C 6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C View Scheme

1.1: dicyclohexyl-carbodiimide / 4-(N,N-dimethlyamino)pyridine / dichloromethane / 20 h / 20 °C / Inert atmosphere 2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 0.67 h / 100 °C / Sealed vial 3.1: 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / tetrachloromethane / 2 h / 100 °C 4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere 4.2: 1 h / 0 - 20 °C 5.1: sodium hydroxide / ethanol / 2 h / 100 °C 5.2: 20 °C / pH ~ 4 6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h 6.2: 0.5 h / 20 °C 7.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C View Scheme

1: sodium hydride / N,N-dimethyl-formamide 2: water; sodium hydroxide / ethanol 3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane 4: trifluoroacetic acid / dichloromethane View Scheme

1: sodium hydride / N,N-dimethyl-formamide 2: water; sodium hydroxide / ethanol 3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane 4: trifluoroacetic acid / dichloromethane View Scheme

1.1: 2,2'-azo-bisisobutyronitrile; N-bromosuccinmide / tetrachloromethane / 2 h / 100 °C 2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere 2.2: 1 h / 0 - 20 °C 3.1: sodium hydroxide / ethanol / 2 h / 100 °C 3.2: 20 °C / pH ~ 4 4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h 4.2: 0.5 h / 20 °C 5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C View Scheme

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h 1.2: 0.5 h / 20 °C 2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C View Scheme