1: 54 percent / dimethylformamide / 1 h / 110 - 120 °C 2: 1.) t-BuOK / 1.) DMF, 0 deg C, 5 min, 2.) DMF, 0 deg C, overnight 3: H2 / 10percent Pd/C / ethanol / 4 h / 60 - 65 °C / 760 Torr 4: AcOH, H2O / 3 h / 40 - 45 °C View Scheme

1: 54 percent / dimethylformamide / 1 h / 110 - 120 °C 2: 1.) t-BuOK / 1.) DMF, 0 deg C, 2.) DMF, 0 deg C, overnight 3: H2 / 10percent Pd/C / ethanol / 4 h / 60 - 65 °C / 760 Torr 4: AcOH, H2O / 3 h / 40 - 45 °C View Scheme

1: 54 percent / dimethylformamide / 1 h / 110 - 120 °C 2: 1.) t-BuOK / 1.) DMF, 0 deg C, 2.) DMF, 0 deg C, overnight 3: H2 / 10percent Pd/C / ethanol / 4 h / 60 - 65 °C / 760 Torr 4: AcOH, H2O / 3 h / 40 - 45 °C View Scheme

1: 54 percent / dimethylformamide / 1 h / 110 - 120 °C 2: 1.) t-BuOK / 1.) DMF, 0 deg C, 5 min, 2.) DMF, 0 deg C, overnight 3: H2 / 10percent Pd/C / ethanol / 4 h / 60 - 65 °C / 760 Torr 4: AcOH, H2O / 3 h / 40 - 45 °C View Scheme

in N,N-dimethyl-formamide T=110 - 120°C; 1 h;