3,5-二甲氧基苯基乙腈合成路线 （共 28 条）
反应条件
1: (i) NaOH, MeOH, (ii) /BRN= 102415/
2: LiAlH4
3: PBr3
View Scheme
参考文献
Bhati,A.
Tetrahedron, 1962 , vol. 18, p. 1519 - 1526
反应条件
1: NaOEt / ethanol
2: aq. H2SO4
3: Py*HCl
View Scheme
参考文献
Bullimore,B.K. et al.
Journal of the Chemical Society [Section] C: Organic, 1967 , p. 1289 - 1293
反应条件
1: 90 percent / 40percent NaOH, H2O2 / ethanol / Heating
2: 98 percent / LiAlH4 / tetrahydrofuran / Heating
View Scheme
参考文献
Bhati,A.
Tetrahedron, 1962 , vol. 18, p. 1519 - 1526
反应条件
sodium hydroxide
6 h; Heating;
参考文献
Bianchi; Alesso; Moltrasio Iglesias
Organic Preparations and Procedures International, 1996 , vol. 28, # 2 p. 230 - 234
反应条件
1.1: NaH / tetrahydrofuran / 1.5 h / 20 °C
1.2: tetrahydrofuran / 20 °C
2.1: 18.30 g / 2-(phenylsulfonyl)-3-phenyloxaziridine / CHCl3 / 24 h / 20 °C
3.1: 72 percent / dioxane / 50 °C
View Scheme
参考文献
Thompson, Andrew M.; Delaney, Amy M.; Hamby, James M.; Schroeder, Mel C.; Spoon, Teresa A.; Crean, Sheila M.; Showalter, H. D. Hollis; Denny, William A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 14 p. 4628 - 4653
反应条件
1: (i) NaOH, MeOH, (ii) /BRN= 102415/
2: LiAlH4
3: (i) PBr3, (ii) /BRN= 774687/, NaH
4: (i) NaOH, MeOH, (ii) (thermolysis), (iii) polyphosphoric acid
View Scheme
参考文献
Bhati,A.
Tetrahedron, 1962 , vol. 18, p. 1519 - 1526
反应条件
1: sodium amide; diethyl ether / anschliessend Erwaermen mit Methyljodid
2: diethyl ether / und Erwaermen des vom Aether befreiten Reaktionsgemisches in Benzol, anschliessendes Behandeln mit wss.HCl und Erhitzen der erhaltenen wss.Loesung
View Scheme
参考文献
Adams; Aycock; Loewe
Journal of the American Chemical Society, 1948 , vol. 70, p. 662
反应条件
1: Raney nickel; methanol; acetic acid / Hydrogenation
2: aqueous HCl
View Scheme
参考文献
Plieninger; Kiefer
Chemische Berichte, 1957 , vol. 90, p. 617,621
