N-2-萘基-1-戊基-1H-吲哚-3-甲酰胺合成路线 （共 4 条）
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 4 h; Inert atmosphere;
参考文献
Blaazer, Antoni R.; Lange, Jos H.M.; Van Der Neut, Martina A.W.; Mulder, Arie; Den Boon, Femke S.; Werkman, Taco R.; Kruse, Chris G.; Wadman, Wytse J.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 10 p. 5086 - 5098
反应条件
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / -10 - 20 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere View Scheme
参考文献
Blaazer, Antoni R.; Lange, Jos H.M.; Van Der Neut, Martina A.W.; Mulder, Arie; Den Boon, Femke S.; Werkman, Taco R.; Kruse, Chris G.; Wadman, Wytse J.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 10 p. 5086 - 5098
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 1.2: 16 h / 0 - 20 °C / Inert atmosphere 2.1: potassium hydroxide / ethanol; water / 20 - 75 °C 3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / -10 - 20 °C / Inert atmosphere 4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere View Scheme
参考文献
Blaazer, Antoni R.; Lange, Jos H.M.; Van Der Neut, Martina A.W.; Mulder, Arie; Den Boon, Femke S.; Werkman, Taco R.; Kruse, Chris G.; Wadman, Wytse J.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 10 p. 5086 - 5098
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere 1.2: 16 h / 0 - 20 °C / Inert atmosphere 2.1: potassium hydroxide / ethanol; water / 20 - 75 °C 3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / -10 - 20 °C / Inert atmosphere 4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere View Scheme
参考文献
Blaazer, Antoni R.; Lange, Jos H.M.; Van Der Neut, Martina A.W.; Mulder, Arie; Den Boon, Femke S.; Werkman, Taco R.; Kruse, Chris G.; Wadman, Wytse J.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 10 p. 5086 - 5098
