4-甲基-[1,1-联苯]-3-甲腈合成路线 （共 24 条）
反应条件
CM-phos; H2O4P(1-)*3K(1+); palladium diacetate; triethylamine in tert-butyl alcohol T=20 - 110°C; Suzuki-Miyaura coupling; Inert atmosphere;
参考文献
Chow, Wing Kin; So, Chau Ming; Lau, Chak Po; Kwong, Fuk Yee
Journal of Organic Chemistry, 2010 , vol. 75, # 15 p. 5109 - 5112
反应条件
1: para-bromotoluene With n-butyllithium in tetrahydrofuran; hexane T=20°C; 0.00277778 h; Inert atmosphere; 2: With tri-isopropoxy-borane in tetrahydrofuran; hexane T=60°C; 0.0166667 h; Inert atmosphere; 3: meta-chloro-benzonitrile With C45H58ClNPPd; potassium hydroxide in tetrahydrofuran; hexane; water T=60°C; Suzuki-Miyaura cross-coupling; 0.166667 h; Inert atmosphereSonication;
参考文献
Shu, Wei; Pellegatti, Laurent; Oberli, Matthias A.; Buchwald, Stephen L.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 45 p. 10665 - 10669
反应条件
triphenylphosphine in tetrahydrofuran; water; acetone; toluene
参考文献
Great Lakes Chemical Konstanz GmbH
Patent: US6121480 A1, 2000 ;
反应条件
caesium carbonate; palladium dichloride in N,N-dimethyl-formamide T=185°C; 20 h; Inert atmosphereSealed tube;
参考文献
Ortgies, Dirk H.; Forgione, Pat
Synlett, 2013 , vol. 24, # 13 art. no. ST-2013-S0280-L, p. 1715 - 1721
反应条件
NiCl2((PPh3)P)2; diisobutylaluminium hydride in tetrahydrofuran T=25°C; 16 h; Yield given;
参考文献
Carini, David J.; Duncia, John V.; Aldrich, Paul E.; Chiu, Andrew T.; Johnson, Alexander L.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2525 - 2547
反应条件
bis-triphenylphosphine-palladium(II) chloride; lithium chloride in N,N-dimethyl-formamide Inert atmosphere;
参考文献
Sanchez, Ana I.; Martinez-Barrasa, Valentin; Burgos, Carolina; Vaquero, Juan J.; Alvarez-Builla, Julio; Terricabras, Emma; Segarra, Victor
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 8 p. 2370 - 2378
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=25°C; Negishi cross-coupling; 20 h; Inert atmosphere;
参考文献
Dong, Zhi-Bing; Manolikakes, Georg; Shi, Lei; Knochel, Paul; Mayr, Herbert
Chemistry - A European Journal, 2010 , vol. 16, # 1 p. 248 - 253
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=25°C; Negishi cross-coupling; 6.5 h; Inert atmosphere;
参考文献
Dong, Zhi-Bing; Manolikakes, Georg; Shi, Lei; Knochel, Paul; Mayr, Herbert
Chemistry - A European Journal, 2010 , vol. 16, # 1 p. 248 - 253
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=25°C; Negishi cross-coupling; 12 h; Inert atmosphere;
参考文献
Dong, Zhi-Bing; Manolikakes, Georg; Shi, Lei; Knochel, Paul; Mayr, Herbert
Chemistry - A European Journal, 2010 , vol. 16, # 1 p. 248 - 253
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=25°C; Negishi cross-coupling; 4 h; Inert atmosphere;
参考文献
Dong, Zhi-Bing; Manolikakes, Georg; Shi, Lei; Knochel, Paul; Mayr, Herbert
Chemistry - A European Journal, 2010 , vol. 16, # 1 p. 248 - 253
